Granulocyte-specific antigens, such as NA1, NA2, NB1, NB2, NC1, ND1, NE1, are a group of antigens specifically expressed only on the granulocytes. Antibodies0 against these are involved in some clinical disorders such as alloimmune neonatal
neutropenia
(ANN), autoimmune neutropenia (AIN), and transfusionrelated acute lung injury (TRALI). We investigated the frequencies of NA1, NA2, NB1, and Mart antigens among Koreans by the granulocyte indirect immunofluorescence test employing flow cytometry.
The
subjects were 105 Koreans (male 65, female 40), whose mean age was 31.7*8.2 years (range 16~57). The antigen and gene frequencies were as follows, NA1. 0.78, 0.53, NA2, 0.75, 0.50, NB1 0.86, 0.62, and Mart, 1.00, 1.00, respectively. The
proportions
of
NB1-positive granulocytes among NB1- positive individuals were variable (range, 27~100%). Through this study, the authors procured granulocyte-specific antigen panel, which is essential in the identification of causative antibody (-ies) in immune
neutropenias.
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